Dr Yi-Wen Chen
Dr Yi-Wen Chen is currently an Associate Professor of Graduate Institute of Clinical Dentistry, National Taiwan University, and the Attending Physician, Department of Dentistry, National Taiwan University Hospital. She completed her PhD degree at the Division of Periodontology, Tokyo Medical and Dental University under Prof. Ishikawa and Professor Izumi’s supervision in 2008. She has been conducted numerous clinical and translational research projects, particularly on the microbiological and immunological aspects of the associations between periodontitis and systemic diseases. Recently, Dr. Chen has identified the specific oral microbiota in patients with Alzheimer’s disease (AD) with next-generation sequencing. In order to understand molecular pathogenesis of AD, she also investigates the effect of P. gingivalis on neuron and microglia cells in vitro. Dr. Chen has been awarded the first prize in research competition at the 2017 ITI World Symposium, and she has been nominated as ITI fellow, director of ITI NTUH study club and chair of ITI NTUH ITI scholar center.
Title: The Associations between Alzheimer’s Disease and Periodontitis from the Aspects of Serology and Oral-microbiota
Alzheimer disease (AD) is a neurodegenerative disease associating with central and peripheral inflammatory responses. Periodontal disease is a bacteria-induced chronic inflammatory disease. Epidemiological studies have reported that patients with periodontal disease have a higher risk of developing AD, but the mechanism was not yet been fully understood. We explored their associations from the aspects of serology and oral microbiota.